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Search Result

Search Results for " estrogen receptor α "

36

Compounds

6

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T62764 Estrogen receptor α antagonist 1
Estrogen receptor α antagonist 1 (compound 35) is a highly selective estrogen receptor α antagonist that acts on estrogen receptor α (IC50: 0.02 μM), estrogen receptor β (IC50. Estrogen receptor α antagonist 1 (compound ...
T6306 Erteberel LY500307 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
T5835 PROTAC ERRα ligand 2 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
T15191 PROTAC ERRα ligand 1 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
PROTAC ERRα ligand 1 is an α (ERRα) antagonist of estrogen-related receptor (IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively).
T16566 Propyl pyrazole triol PPT Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: ...
T11230 ERRα antagonist-1 ERR+/- antagonist-1,ERRa antagonist-1 Estrogen/progestogen Receptor
ERRα antagonist-1 (ERR+/- antagonist-1) is a high-affinity, selective antagonist of the estrogen-related receptor α (ERRα). It effectively prevents the interaction of ERRα with both Proliferator-activated Receptor γ Coac...
T13700 GDC-0927 Racemate SRN-927 Racemate Others
GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.
T39368 GNE-149
GNE-149 is an orally bioavailable compound that acts as a full antagonist of estrogen receptor α (ERα) with an IC50 of 0.053 nM. It is also classified as a selective estrogen receptor degrader (SERD). GNE-149 holds poten...
T79109 Estrogen receptor modulator 8 Estrogen Receptor/ERR
Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells) and effectively hampers MCF-7 cell proliferation (IC50 = 0....
T25367 EM-800 EM800,EM 800
EM-800 is a high affinity ligand for estrogen receptor-α (ERα), the prodrug of EM-652. EM-800 independently inhibited the growth of E1-stimulated ZR-75-1 xenograft tumors in nude mice.
T63277 Estrogen receptor antagonist 2
Estrogen receptor antagonist 2 is a selective down-regulator of estrogen receptor. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. estrogen receptor antagonist 2 has re...
T36913 17-Epiestriol
17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16α-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor α (ERα) and ERβ with relative binding af...
T17940 Estrone-N-O-C1-amido ERα ligand 1 Others
Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-O-C1-amido (ERα ligand 1) forms a complex with the cIAP1 li...
T39298 Raloxifene 4-Monomethyl Ether
Raloxifene 4-Monomethyl Ether (Compound 37) is a derivative of Raloxifene which acts as an inhibitor of estrogen receptor α. It effectively suppresses the activity of MCF-7 cells, exhibiting an IC50 value of 1 μM and a p...
T62490 OBHS
OBHS is an inhibitor of estrogen receptor alpha (ERα).
T63582 Estrogen receptor antagonist 1
Estrogen receptor antagonist 1 is a potent antagonist of the estrogen receptor. Estrogen receptor antagonist 1 has shown research potential in breast cancer disease.
T22159 TCS HDAC6 20b
TCS HDAC6 20b is a HDAC6 -selective inhibitor that blocks the growth of estrogen receptor α-positive breast cancer MCF-7 cells [1].
T40349 DS45500853
DS45500853, an estrogen-related receptor α (ERRα) agonist, acts as an inhibitor of the binding interaction between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain ...
T79382 ER degrader 6 Estrogen Receptor/ERR
ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the microtubule network, inhibiting tubulin polymerization, and effe...
T39203 Raloxifene 6-Monomethyl Ether
Compound 7, or Raloxifene 6-Monomethyl Ether, is a derivative of Raloxifene that effectively inhibits estrogen receptor α. It also displays the inhibitory effects on MCF-7 cells, with an IC50 of 250 nM and a pIC50 of 6.6...
T61923 ERRα antagonist-2
ERRα antagonist-2 (Compound 11) is a potential Reverse agonist of ERR α (estrogen receptor related receptor α) (IC50=0.80 μ M). ERRα antagonist-2 can inhibit the migration and invasion of ER-negative MDA-MB-231 cells. ER...
T39838 (S,R,S)-AHPC-C7-amine VH032-C7-amine,(S,R,S)-AHPC-C7-amine
(S,R,S)-AHPC-C7-amine, also known as VH032-C7-amine, is a chemically synthesized conjugate that functions as an E3 ligase ligand-linker. This compound combines the VH032-based VHL ligand with a specific linker designed f...
T39651 (S,R,S)-AHPC-C5-NH2 (S,R,S)-AHPC-C5-NH2,VH032-C5-NH2
(S,R,S)-AHPC-C5-NH2, also known as VH032-C5-NH2, is a synthetic compound designed as an E3 ligase ligand-linker conjugate. This compound combines the VH032-based von Hippel-Lindau (VHL) ligand with a linker, enabling it ...
T83907 10-Chloroestra-1,4-diene-3,17-dione 10-chloro-1,4-Estradiene
10-Chloroestra-1,4-diene-3,17-dione acts as an estrogen receptor α (ERα) agonist, enhancing reporter gene expression in S. cerevisiae with an EC50 of 0.36 nM for the human receptor. Additionally, it functions as an aroma...
T60441 DK3
DK3 is a potent and selective agonist of estrogen-related receptor alpha (ERRα). ERRα is a potential drug target for cancer and metabolic diseases [1].
T18605 PROTAC ERα Degrader-2 Others
PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cel...
T60827 TPBM
TPBM is a potent inhibitor of estrogen receptor α (ERα). The IC 50 value of TPBM for 17β-estradiol (E2)-ERα is 9 μM. TPBM is not toxic to cells and reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TP...
T18697 SNIPER(ER)-87 Others
SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effecti...
T60759 DS20362725
DS20362725 is an agonist of estrogen-related receptor α (ERRα) that is able to be used for the metabolic disorders research, for example, type 2 diabetes mellitus (T2DM). The IC 50 value of DS20362725 inhibiting the bind...
T74375 PROTAC ERα Y537S degrader-1
PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader [1] .
T64026 ERα antagonist 1
ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and induces apoptosis.
T62106 (Rac)-ErSO-DFP
(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP overactivates ERα+-dependent anticipatory unfolded protein responses and exhibits anti-estrogen receptor alpha-po...
T74060 AZ'6421
AZ'6421, functioning as a Proteolysis Targeting Chimera (PROTAC), selectively degrades estrogen receptor alpha, demonstrating potent anti-tumor activity by inhibiting uncontrolled cellular proliferation characteristic of...
T35783 Zearalenone-13C18 Zearalenone-13C18
Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to huma...
TMIH-0414 Ospemifene-d4
Ospemifene-d4 is a deuterated compound of Ospemifene. Ospemifene has a CAS number of 128607-22-7. Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate t...
T35676 17β-hydroxy Exemestane
17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (...

Compounds

Estrogen receptor α antagonist 1
T62764
Synonym:
Target:
Erteberel
T6306
Synonym: LY500307
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
PROTAC ERRα ligand 2
T5835
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
PROTAC ERRα ligand 1
T15191
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Propyl pyrazole triol
T16566
Synonym: PPT
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
ERRα antagonist-1
T11230
Synonym: ERR+/- antagonist-1,ERRa antagonist-1
Target: Estrogen/progestogen Receptor
GDC-0927 Racemate
T13700
Synonym: SRN-927 Racemate
Target: Others
GNE-149
T39368
Synonym:
Target:
Estrogen receptor modulator 8
T79109
Synonym:
Target: Estrogen Receptor/ERR
EM-800
T25367
Synonym: EM800,EM 800
Target:
Estrogen receptor antagonist 2
T63277
Synonym:
Target:
17-Epiestriol
T36913
Synonym:
Target:
Estrone-N-O-C1-amido
T17940
Synonym: ERα ligand 1
Target: Others
Raloxifene 4-Monomethyl Ether
T39298
Synonym:
Target:
OBHS
T62490
Synonym:
Target:
Estrogen receptor antagonist 1
T63582
Synonym:
Target:
TCS HDAC6 20b
T22159
Synonym:
Target:
DS45500853
T40349
Synonym:
Target:
ER degrader 6
T79382
Synonym:
Target: Estrogen Receptor/ERR
Raloxifene 6-Monomethyl Ether
T39203
Synonym:
Target:
ERRα antagonist-2
T61923
Synonym:
Target:
(S,R,S)-AHPC-C7-amine
T39838
Synonym: VH032-C7-amine,(S,R,S)-AHPC-C7-amine
Target:
(S,R,S)-AHPC-C5-NH2
T39651
Synonym: (S,R,S)-AHPC-C5-NH2,VH032-C5-NH2
Target:
10-Chloroestra-1,4-diene-3,17-dione
T83907
Synonym: 10-chloro-1,4-Estradiene
Target:
DK3
T60441
Synonym:
Target:
PROTAC ERα Degrader-2
T18605
Synonym:
Target: Others
TPBM
T60827
Synonym:
Target:
SNIPER(ER)-87
T18697
Synonym:
Target: Others
DS20362725
T60759
Synonym:
Target:
PROTAC ERα Y537S degrader-1
T74375
Synonym:
Target:
ERα antagonist 1
T64026
Synonym:
Target:
(Rac)-ErSO-DFP
T62106
Synonym:
Target:
AZ'6421
T74060
Synonym:
Target:
Zearalenone-13C18
T35783
Synonym: Zearalenone-13C18
Target:
Ospemifene-d4
TMIH-0414
Synonym:
Target:
17β-hydroxy Exemestane
T35676
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T13542 α-Zearalenol Estrogen Receptor/ERR
α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).
T0760 Cholesterol Cholesterin,Cholesteryl alcohol Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us...
TN1567 Delphinidin chloride Estrogen Receptor/ERR , VEGFR
Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va...
T36914 2-Hydroxyanthraquinone Others
2-Hydroxyanthraquinone is an anthraquinone that has been found inSpermacoce latifoliaand has antibacterial and estrogenic activities.1,2It is active againstB. subtilisandB. cereus(MICs = 1.9 and 62.5 μg/ml, respectively)...
TN6366 Lupinalbin A
Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokine...
TN3084 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone Estrogen Receptor/ERR , Others
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone showed strong anti-proliferation effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 uM. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-dipren...

Natural Products

α-Zearalenol
T13542
Synonym:
Target: Estrogen Receptor/ERR
Cholesterol
T0760
Synonym: Cholesterin,Cholesteryl alcohol
Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR
Delphinidin chloride
TN1567
Synonym:
Target: Estrogen Receptor/ERR, VEGFR
2-Hydroxyanthraquinone
T36914
Synonym:
Target: Others
Lupinalbin A
TN6366
Synonym:
Target:
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone
TN3084
Synonym:
Target: Estrogen Receptor/ERR, Others

Recombinant Proteins

Species：
Human (1)
Expression System：
E. coli (1)
Tag：
N-6xHis (1)
Cat No. Product Name Species Expression System
TMPJ-00762 ER alpha Protein, Human, Recombinant (His) Human E. coli
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a...
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